How does Neuromodulation work? part 2

•          Percutaneous tibial nerve stimulation (PTNS) employs electrical stimulation of the sacral nerve plexus to treat urinary urgency, frequency and urge incontinence. 
•              The intervention with PTNS consist of delivering impulses accessing the S1-S3 junction of the sacral nerve plexus via the less invasive route of the tibial nerve.
•          The tibial nerve is accessed via a fine (34G) needle electrode inserted slightly above the ankle.  This anatomic area, long recognized as the “bladder center”, has projections to the sacral nerve plexus creating a feedback loop that neuromodulates bladder innervation.
    However  the exact mechanism of action of neuromodulation remains unclear.