How does Neuromodulation work? part 1

•          The bladder and pelvic floor receive most of their innervations from the pudendal nerve, with 70% coming from the S3 nerve root and 30% from S2 and possibly S4. 
•              Sacral parasympathetic preganglionic fibers in the pelvic nerve provide the major excitatory input to the bladder. 
•               Fibers originating in the thoracolumbar sympathetic pathways provide the inhibitory input. 
•              Afferent pelvic pathways are composed of small, myelinated A fibers and unmyelinated C-fibers. 

•              These pathways, transmitting signals from the bladder mechanoreceptors, pelvic visceral organs, and somatic pathways, provide signals for the voluntary control of micturition.