SGYY, a Chinese herbal formula, significantly improves the maximal
intracavernous pressure in a rat arteriogenic ED model. The underlying
mechanism of action of SGYY involves increasing the expression of nNOS, iNOS, eNOS,
and cGMP, and reducing PDE5 expression. Therefore, the modulation of the
NOS-cGMP pathway plays a major role in SGYY action for treating ED.
UROLOGY 79: 241.e1–241.e6, 2012. © 2012 Elsevier Inc
